GLP-1 (glucagon-like peptide-1) agonists have become a tool for sustainable weight loss and metabolic support. Although these medications were first approved for type 2 diabetes, clinicians now prescribe them off-label to help eligible adults achieve healthy, long-term weight reduction. Before you explore this treatment option, it’s essential to know who generally qualifies and what the initial phases of therapy look like.
What Medical Criteria Determine GLP-1 Eligibility?
Most insurance guidelines and clinical protocols use body mass index (BMI) and weight-related health conditions to determine GLP-1 eligibility. Adults with a BMI of 30 or higher are typically considered candidates. Those with a BMI between 27 and 29.9 may also qualify if they have at least one weight-related comorbidity, such as hypertension, high cholesterol, sleep apnea, or prediabetes.
Though women’s health conditions such as menopause, perimenopause, and polycystic ovarian syndrome (PCOS) are often excluded by many physicians as weight-related conditions, they are often linked with weight and metabolic syndromes, and practices that are responsive to the issues of women’s health will treat them as such.
In addition to BMI thresholds, providers review your overall health history. Conditions like pancreatitis, a personal or family history of medullary thyroid carcinoma, or certain gastrointestinal disorders may contraindicate GLP-1 use. A thorough medical evaluation, including blood work and a review of current medications, ensures that GLP-1 therapy is safe and appropriate for your unique profile.
How Does Your Provider Assess Suitability for Treatment?
The assessment process usually begins with an in-depth consultation. Your clinician will ask about past diet and exercise attempts, existing medical conditions, and any medication allergies or adverse reactions. They will also measure your baseline metrics, weight, waist circumference, blood pressure, and key labs like fasting glucose and HbA1c.
Next, potential benefits and side effects are discussed. You’ll learn about common reactions like nausea or mild gastrointestinal discomfort. The plan is to start at a low dose and gradually increase it to improve tolerance. Your provider may also review lifestyle factors, sleep habits, stress levels, and physical activity to tailor a comprehensive support plan.
Finally, a treatment agreement outlines expectations for follow-up visits, medication adherence, and monitoring. Regular in-person or virtual check-ins help track progress, adjust dosing, and address any emerging concerns.
What Initial Changes Should You Anticipate During GLP-1 Therapy?
As you begin GLP-1 therapy, many patients notice reduced appetite within the first week. Meals that once felt insufficient may now keep you satisfied longer, and sugar cravings often diminish. It’s common to experience mild nausea, especially as your body adjusts to the medication. Staying hydrated and eating smaller, frequent meals can ease this transition.
Within the first month, you may observe gradual weight loss, often around 2 to 5 percent of your starting weight. Energy levels can shift too; some people feel a modest dip as their bodies adapt, while others report improved focus and fewer mid-day slumps. Tracking food intake, physical activity, and mood in a journal or app helps you notice patterns and share detailed feedback with your provider.
By month three, many see more significant results: continued weight loss, better blood-sugar readings, and a clearer relationship with hunger cues. At this point, your clinician may adjust your dose to optimize benefits. Throughout these stages, open communication is key; report any bothersome side effects, celebrate milestones, and ask questions to stay empowered on your journey.
Take the Next Step Toward Informed Care with Konk Slim
Is GLP-1 therapy right for you? Check out Konk Sleep to explore the Konk Slim program, learn about eligibility, and access the guidance you need to begin your journey toward effective, science-backed weight management.